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1 The same mechanisms apply to the hip, which carries 2.5 to 3 times body weight when walking, so the benefit is biologically plausible, but Wegovy hasnt been tested in a published hip trial
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It is not just about willpower
Ganglionic blockers block the open channel pore, and do not interact with the acetylcholine receptor, in contrast to the mechanism of action of non-depolarizing skeletal muscle relaxants such as rocuronium and and vecuronium, which are competitive antagonists of the nicotinic acetylcholine receptor (Giniatullin et al, 2000)
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